SARS?CoV?2, the pandemic coronavirus: Molecular and structural insights

The outbreak of a novel coronavirus associated with acute respiratory disease, called COVID-19, marked the introduction third spillover an animal (CoV) to humans in last two decades. genome analysis various bioinformatics tools revealed that causative pathogen (SARS-CoV-2) belongs subgenus Sarbecovirus genus Betacoronavirus, highly similar as bat and receptor-binding domain (RBD) spike glycoprotein Malayan pangolin coronavirus. Based on its genetic proximity, SARS-CoV-2 is likely have originated from bat-derived CoV transmitted via unknown intermediate mammalian host, probably pangolin. Further, protein S1/S2 cleavage site has acquired polybasic furin which absent suggesting natural selection either host before zoonotic transfer or following transfer. In current review, we recapitulate preliminary opinion about origin life cycle SARS-CoV-2, roles virus proteins pathogenesis, commonalities, differences between different corona viruses. Moreover, crystal structures unique characteristics differentiating it other CoVs are discussed. Our review also provides comprehensive information molecular aspects including secondary protein–protein interactions can be useful understand aggressive spread SARS-CoV-2. mutations haplotypes reported summarized evolution.